Abstract: In this study we compare two strategies for controlling the spread of carcinogenic HPV in the population, while minimizing cost. The research is conducted via a cost analysis of a mandatory vaccination policy vs. a mass-media awareness campaign, each individually modeled with a system of differential equations. We use qualitative analysis to derive the respective control reproductive numbers, and numerical analysis to obtain the total costs of vaccination, education, high sexual activity, and expected cancer treatment costs for infected females in both models.