Sarah E. Evans, PhD Assistant Professor of Biochemistry

Sarah E. Evans, PhD

evans51@canisius.edu
(716) 888-2342

Teaching Interests

Biochemistry and bioinorganic chemistry. Research interests include metal regulatory pathways in bacterial cells. In particular, determining the metal- and DNA-binding properties of a vital transcription factor from Borrelia burgdorferi, the bacteria that causes Lyme disease, and uses of metal complexes as tools to model biological events.

Research Interests

Metals play an important role in biological systems and organisms tightly regulate metal concentrations in order to prevent deficiency and toxicity.  We will be determining the metal- and DNA-binding properties of a vital transcription factor from Borrelia burgdorferi, the bacteria that causes Lyme disease. 

 

In cells, DNA-protein crosslinks cans occur when the cells are experiencing oxidative stress.  These crosslinks interrupt cellular functions such as transcription and replication.  We will be using metal complexes to produce oxidative conditions and study the potential crosslinks formed between DNA bases and modified amino acids.