Timothy Gregg, PhD Associate Professor of Organic Chemistry

Timothy Gregg, PhD

PhD, University of Arizona
(716) 888-2259

Teaching Interests

Teaching areas include organic chemistry and spectroscopy. Research interests include organic synthesis, reaction mechanisms and novel transformations involving rhodium carbenoid chemistry.

Research Interests

Research into medicines, biochemical probes and polymers relies on Organic Synthesis to be able to design and build new molecules with specific shapes and properties. Dr. Gregg's organic synthesis research focuses on finding new reactions, showing the types of products that can be prepared with them and studying the chemical mechanisms by which they occur.

Dr. Gregg's recent work focuses on allenes, which react in high yield to give interesting cyclopropane products. Applications of this work include synthesizing novel compounds with antiviral activity.

Allene cyclopropanation using chiral rhodium catalysis

The mechanism of cyclopropanation can be studied using computer simulations that show, in great detail, the movement of atoms as starting materials are converted into products.

A computer-generated model of cyclopropanation in progress


Gregg, T. M.; Farrugia, M. K.; Frost, J. R., Rhodium-mediated enantioselective cyclopropanation of allenes. Org. Lett. 2009, 11, 4434-4436.

Nowlan, D. T.; Gregg, T. M.; Davies, H. M. L.; Singleton, D. A., Isotope effects and the nature of selectivity in rhodium-catalyzed cyclopropanations. J. Am. Chem. Soc. 2003, 125, 15902-15911.

Davies, H. M. L.; Gregg, T. M., Asymmetric synthesis of (+)- Indatraline using rhodium-catalyzed C-H activation. Tetrahedron Lett. 2002, 43, 4951-4953.